Hasifah Nasuuna and Fazila Ikwaput also bagged a brace each for the Uganda team, while Fauzia Najjemba and Amina Nababi scored one goal each.
“I am happy that I have scored five goals today that have helped my team pick a big win. We shall keep working hard in the tournament because our target is to win the trophy,” said Nalukenge.
Uganda now lead Group B with a better goal difference than Kenya who beat Ethiopia 2-0 in an earlier match.
The regional tournament started on Saturday with Burundi humbling Zanzibar 5-0 before defending champions Tanzania thumped debut making South Sudan 9-0.